Bridges represent a critical facet when determining a community’s resilience to a disaster and its ability to resume normal activities. The accurate prediction of the future condition of bridges is an important part of any bridge management system. Past bridges inspection data along with information on any repair and/or retrofit can provide a baseline for predicting their future conditions. To develop a reasonable estimate for future bridge safety, this paper describes a creation of the information system that get insight into the critical infrastructure elements and can identify the losses that can be caused by earthwuake. This system includes bridge infrastructure network elements from the N. Macedonian region. An extended database of bridge population (created for the Infra-NAT project www.infra-nat.eu) is developed through a data collection form and allows for a detailed exposure model of the bridge network to be compiled. The database is upgraded with retaining walls that are important parts of the regional transportation network. By considering the general characteristics of the bridge, a representative sample of bridges is chosen to develop fragility functions for bridges exposed to seismic hazard. To estimate the physical vulnerability and potential economic losses due to seismic hazards to all transportation network, seismic risk assessment toll is developed. The results enable a better understanding of the relevance of the vulnerability level of critical infrastructure in the analyzed region, correlating it to the corresponding levels of development, as well as other socio-economic variables.